产品货号：
Z36434
中文名称：
RELB抗体
英文名称：
Anti-RELB Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-RELB Antibody |
| 指标别名 | I REL;IREL;RELB;Transcription factor RelB |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF,IP,FCM |
| 基因名称 | RELB |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human RelB |
| 实际分子量 | 70KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | RELB(v-rel reticuloendotheliosis viral oncogene homolog B) is also known as IREL.The International Radiation Hybrid Mapping Consortium assigned the RELB gene to chromosome 19.By RT-PCR and immunocytochemical analyses,Clark et al.(1999) showed that RELB expression correlated with dendritic cell activation.NF-kappa-B-inducing kinase is required for osteoclastogenesis in response to pathologic stimuli.Vaira et al.(2008) found that overexpression of Relb,but not Rela,rescued differentiation of mouse Nik -/- osteoclast precursors,indicating that blockade of the alternative NF-kappa-B pathway,rather than the classical NF-kappa-B pathway,is responsible for the osteoclastogenic defect in the absence of Nik.Using Relb -/- mice,they showed that Relb itself was required for Rankl-induced osteoclastogenesis in vitro and for TNF-induced bone resorption in vivo.Both Relb -/- and Nik -/- mice were resistant to tumor-mediated osteolysis.Vaira et al.(2008) concluded that the alternative NF-kappa-B pathway,via RELB,plays an essential and unique role in RANKL signaling toward osteoclast development. |
| Uniprot ID | Q01201 |
| 基因名全称 | Transcription factor RelB |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:20～100ICC/IF Immunocytochemistry/Immunofluorescence(ICC/IF) 1:20～100 Immunocoprecipitation 1:20 Flow cytometry (FCM) 1:20 |
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